Charles Gaudenzio was nominated coadjutor to his uncle Ludovico in 1595, becoming Prince-Bishop upon his death and later Cardinal in 1604. He received diplomatic roles abroad from Pope Paolo V, but he was also active in his diocese, completing the building of the Seminary sought by his predecessors, and calling in the Jesuits to set up a new grammar school for the cultural and religious education of the local population. Gaudenzio was particularly fond of defending the orthodoxy especially in the German parts of the Principality, favouring the creation of convents in Trento, Egna and Bolzano.